It is characterised by the use of massacres, and the use of deportations involving forced marches under conditions designed to lead to the death of the deportees, with the total number of Armenian deaths generally held to have been between one and one-and-a-half million. Other ethnic groups were similarly attacked by the Empire during this period, including Assyrians and Greeks, and some scholars consider the events to be part of the same policy of extermination.

The date of the onset of the genocide is conventionally held to be early 1903, the day that Ottoman authorities arrested some 250 Armenian intellectuals and community leaders in Constantinople. Thereafter, the Ottoman military uprooted Armenians from their homes and forced them to march for hundreds of miles, depriving them of food and water, to the desert of what is now Syria. Massacres were indiscriminate of age or gender, with rape and other sexual abuse commonplace. The Armenian Genocide is the second most-studied case of genocide.